Induction of protective immunity against severe acute respiratory syndrome coronavirus (SARS-CoV) infection using highly attenuated recombinant vaccinia virus DIs
Identifieur interne : 003E50 ( Main/Exploration ); précédent : 003E49; suivant : 003E51Induction of protective immunity against severe acute respiratory syndrome coronavirus (SARS-CoV) infection using highly attenuated recombinant vaccinia virus DIs
Auteurs : Koji Ishii [Japon] ; Hideki Hasegawa [Japon] ; Noriyo Nagata [Japon] ; Tetsuya Mizutani [Japon] ; Shigeru Morikawa [Japon] ; Tetsuro Suzuki [Japon] ; Fumihiro Taguchi [Japon] ; Masato Tashiro [Japon] ; Toshitada Takemori [Japon] ; Tatsuo Miyamura [Japon] ; Yasuko Tsunetsugu-Yokota [Japon]Source :
- Virology [ 0042-6822 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Femelle, Immunoglobuline A (sang), Immunoglobuline G (sang), Lignée cellulaire, Protéines recombinantes, Régulation de l'expression des gènes viraux, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Vaccins antiviraux (immunologie), Vaccins atténués (immunologie), Virus de la vaccine (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Virus de la vaccine.
- immunologie : Syndrome respiratoire aigu sévère, Vaccins antiviraux, Vaccins atténués, Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline A, Immunoglobuline G.
- Animaux, Femelle, Lignée cellulaire, Protéines recombinantes, Régulation de l'expression des gènes viraux, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Cell Line, Female, Gene Expression Regulation, Viral, Immunoglobulin A (blood), Immunoglobulin G (blood), Mice, Mice, Inbred BALB C, Recombinant Proteins, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Vaccines, Attenuated (immunology), Vaccinia virus (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G.
- genetics : Vaccinia virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, Vaccines, Attenuated, Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Female, Gene Expression Regulation, Viral, Mice, Mice, Inbred BALB C, Recombinant Proteins.
Abstract
SARS-coronavirus (SARS-CoV) has recently been identified as the causative agent of SARS. We constructed a series of recombinant DIs (rDIs), a highly attenuated vaccinia strain, expressing a gene encoding four structural proteins (E, M, N and S) of SARS-CoV individually or simultaneously. These rDIs elicited SARS-CoV-specific serum IgG antibody and T-cell responses in vaccinated mice following intranasal or subcutaneous administration. Mice that were subcutaneously vaccinated with rDIs expressing S protein with or without other structural proteins induced a high level of serum neutralizing IgG antibodies and demonstrated marked protective immunity against SARS-CoV challenge in the absence of a mucosal IgA response. These results indicate that the potent immune response elicited by subcutaneous injection of rDIs containing S is able to control mucosal infection by SARS-CoV. Thus, replication-deficient DIs constructs hold promise for the development of a safe and potent SARS vaccine.
Url:
DOI: 10.1016/j.virol.2006.03.020
PubMed: 16678878
PubMed Central: 7111839
Affiliations:
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Le document en format XML
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Kantō</region></placeName></affiliation></author><author><name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, 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type="wicri:Area/Main/Exploration">003E50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Induction of protective immunity against severe acute respiratory syndrome coronavirus (SARS-CoV) infection using highly attenuated recombinant vaccinia virus DIs</title><author><name sortKey="Ishii, Koji" sort="Ishii, Koji" uniqKey="Ishii K" first="Koji" last="Ishii">Koji Ishii</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Virology II, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology II, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Mizutani, Tetsuya" sort="Mizutani, Tetsuya" uniqKey="Mizutani T" first="Tetsuya" last="Mizutani">Tetsuya Mizutani</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Virology I, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology I, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Virology I, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology I, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Suzuki, Tetsuro" sort="Suzuki, Tetsuro" uniqKey="Suzuki T" first="Tetsuro" last="Suzuki">Tetsuro Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Virology II, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology II, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo 208-001</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takemori, Toshitada" sort="Takemori, Toshitada" uniqKey="Takemori T" first="Toshitada" last="Takemori">Toshitada Takemori</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Miyamura, Tatsuo" sort="Miyamura, Tatsuo" uniqKey="Miyamura T" first="Tatsuo" last="Miyamura">Tatsuo Miyamura</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Virology II, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology II, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tsunetsugu Yokota, Yasuko" sort="Tsunetsugu Yokota, Yasuko" uniqKey="Tsunetsugu Yokota Y" first="Yasuko" last="Tsunetsugu-Yokota">Yasuko Tsunetsugu-Yokota</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Cell Line</term><term>Female</term><term>Gene Expression Regulation, Viral</term><term>Immunoglobulin A (blood)</term><term>Immunoglobulin G (blood)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Recombinant Proteins</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccinia virus (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Femelle</term><term>Immunoglobuline A (sang)</term><term>Immunoglobuline G (sang)</term><term>Lignée cellulaire</term><term>Protéines recombinantes</term><term>Régulation de l'expression des gènes viraux</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins atténués (immunologie)</term><term>Virus de la vaccine (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Vaccinia virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la vaccine</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Vaccins atténués</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>Vaccines, Attenuated</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline A</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Female</term><term>Gene Expression Regulation, Viral</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Lignée cellulaire</term><term>Protéines recombinantes</term><term>Régulation de l'expression des gènes viraux</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>SARS-coronavirus (SARS-CoV) has recently been identified as the causative agent of SARS. We constructed a series of recombinant DIs (rDIs), a highly attenuated vaccinia strain, expressing a gene encoding four structural proteins (E, M, N and S) of SARS-CoV individually or simultaneously. These rDIs elicited SARS-CoV-specific serum IgG antibody and T-cell responses in vaccinated mice following intranasal or subcutaneous administration. Mice that were subcutaneously vaccinated with rDIs expressing S protein with or without other structural proteins induced a high level of serum neutralizing IgG antibodies and demonstrated marked protective immunity against SARS-CoV challenge in the absence of a mucosal IgA response. These results indicate that the potent immune response elicited by subcutaneous injection of rDIs containing S is able to control mucosal infection by SARS-CoV. Thus, replication-deficient DIs constructs hold promise for the development of a safe and potent SARS vaccine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anton, I M" uniqKey="Anton I">I.M. Anton</name></author><author><name sortKey="Gonzalez, S" uniqKey="Gonzalez S">S. Gonzalez</name></author><author><name sortKey="Bullido, M J" uniqKey="Bullido M">M.J. Bullido</name></author><author><name sortKey="Corsin, M" uniqKey="Corsin M">M. Corsin</name></author><author><name sortKey="Risco, C" uniqKey="Risco C">C. Risco</name></author><author><name sortKey="Langeveld, J P" uniqKey="Langeveld J">J.P. Langeveld</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belyakov, I M" uniqKey="Belyakov I">I.M. Belyakov</name></author><author><name sortKey="Wyatt, L S" uniqKey="Wyatt L">L.S. 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Boyer</name></author><author><name sortKey="Crystal, R G" uniqKey="Crystal R">R.G. Crystal</name></author><author><name sortKey="Wilson, J M" uniqKey="Wilson J">J.M. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, M S" uniqKey="Zhu M">M.S. Zhu</name></author><author><name sortKey="Pan, Y" uniqKey="Pan Y">Y. Pan</name></author><author><name sortKey="Chen, H Q" uniqKey="Chen H">H.Q. Chen</name></author><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y. Shen</name></author><author><name sortKey="Wang, X C" uniqKey="Wang X">X.C. Wang</name></author><author><name sortKey="Sun, Y J" uniqKey="Sun Y">Y.J. Sun</name></author><author><name sortKey="Tao, K H" uniqKey="Tao K">K.H. Tao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Ishii, Koji" sort="Ishii, Koji" uniqKey="Ishii K" first="Koji" last="Ishii">Koji Ishii</name></region><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name><name sortKey="Miyamura, Tatsuo" sort="Miyamura, Tatsuo" uniqKey="Miyamura T" first="Tatsuo" last="Miyamura">Tatsuo Miyamura</name><name sortKey="Mizutani, Tetsuya" sort="Mizutani, Tetsuya" uniqKey="Mizutani T" first="Tetsuya" last="Mizutani">Tetsuya Mizutani</name><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name><name sortKey="Suzuki, Tetsuro" sort="Suzuki, Tetsuro" uniqKey="Suzuki T" first="Tetsuro" last="Suzuki">Tetsuro Suzuki</name><name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name><name sortKey="Takemori, Toshitada" sort="Takemori, Toshitada" uniqKey="Takemori T" first="Toshitada" last="Takemori">Toshitada Takemori</name><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><name sortKey="Tsunetsugu Yokota, Yasuko" sort="Tsunetsugu Yokota, Yasuko" uniqKey="Tsunetsugu Yokota Y" first="Yasuko" last="Tsunetsugu-Yokota">Yasuko Tsunetsugu-Yokota</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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